
Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders (English, National Academies of Sciences Engineeri | Health, Medicine Division | Board on Health Sciences Policy)
by National Academies of Sciences Engineeri | Health
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Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the phar…
ISBN: 9780309455138
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